Latest Research Studies


Deep Brain Stimulation for OCD

Development of Adaptive Deep Brain Stimulation for Treatment-Resistant OCD

Baylor College of Medicine (BCM) is conducting a research study for treatment-resistant OCD patients using Deep Brain Stimulation (DBS) funded by the National Institutes of Health (NIH) BRAIN Initiative. For the 10-25% of patients that do not respond to Cognitive Behavioral Therapy (CBT) with Exposure with Response Prevention (ERP) and multiple SRIs.

DBS is a surgical procedure when small electrodes are implanted deep into the brain, which provides electrical stimulations to specific areas of the brain to help patients control their OCD symptoms. This study will be using an adaptive DBS (aDBS) that will be able to automatically adjust the stimulation strength in real-time, cutting out offices visits in comparison to traditional DBS.

The purpose of this study is to see if an aDBS can help control OCD symptoms in patients that do not respond to other treatments as well as detect OCD symptoms, adverse side effects and automatically lower and raise stimulation in the brain.

Click here to get more information about this study.


Adult Subjects with OCD

The purpose of this study is to compare the efficacy of BHV-4157 versus placebo in subjects with OCD Click here to learn more.


Measuring Automated Behavioral Observations & Vocal Expressions

The investigators propose to synchronize automated measurements of behavior (head, body, and face dynamics, gaze, and vocal prosody) with simultaneous recordings of brain activity in clinically relevant contexts. Click here to learn more.


Locating Biomarkers in OCD through Behavioral Task

Subjects that have a diagnosis of OCD will participate in a clinical interview and cognitive tasks, during which they will be exposed to their individual OC stressors or will be asked to make decisions related to information value and quantity while measuring neural activity and filming facial reactions. This will assist investigators to look for biomarkers of that change. This study offers a unique opportunity to develop biomarkers for key domains of OCD, and other neuropsychiatric disorders, that are grounded in brain neurocircuitry at the individual-patient level. Click here to learn more.


DBS of the Lateral Habenula in Treatment-Resistant Depression

This research study will investigate the safety, tolerability, and benefit of bilateral deep brain stimulation (DBS) to the lateral habenula in subjects with treatment-resistant major depression (TRD) secondary to either nonpsychotic unipolar major depressive disorder (MDD), or bipolar disorder (BD) I. Click here to learn more.


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Videos: Research

Choose a title below to view a video for more information on various OCD topics.

The drug candidate, BHV-4157, is in clinical trials at Baylor College of Medicine at 50+ centers nationwide. Thanks to Ivanhoe producer Donna Parker, for interviewing Elizabeth McIngvale, Ph.D., an OCD patient and Baylor psychologist; and Eric Storch, Ph.D., Baylor investigator. Thanks to KPRC 2 News medical reporter Haley Hernandez for bringing the story to local viewers in Houston.